Velpatasvir is a Direct-Acting Antiviral (DAA) medication which used to treat chronic Hepatitis C Virus infection (HCV) along with the other antiviral Sofosbuvir 400mg. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common and affecting 72% of all chronic HCV patients.
Velpatasvir acts as a defective substrate for NS5A (Non-Structural Protein 5A), a non-enzymatic viral protein that plays a key role in Hepatitis C Virus replication, assembly, and modulation of host immune responses. The substance blocks NS5A, a protein necessary for hepatitis C virus replication in blood.
Velpatasvir has a higher barrier to resistance than the first generation NS5A inhibitors, such as Ledipasvir and Daclatasvir. Velpatasvir (Epclusa) is the only available Direct-Acting Antiviral within combination of sofosbuvir which is another direct acting antiviral.
Epclusa (Sofosbuvir 400mg with Velpatasvir 100mg) is the first combination HCV product indicated for the treatment of all genotypes of Hepatitis C with or without cirrhosis. It is also currently the most potent HCV antiviral medication on the market with a sustained virologic response (SVR) after 12 weeks of therapy of 93-99% depending on genotype. Pharmacokinetics
When orally intake Velpatasvir with Sofosbuvir, it reaches the highest blood plasma levels after 3 hours. Plasma protein binding is over 99.5%. It is slowly metabolized the liver enzymes of CYP2C8, CYP2B6, and CYP3A4. Over 98% of the circulating substance is Velpatasvir itself, while mono hydroxylated and demethylated metabolites have been identified in human blood plasma and faeces.
The Velpatasvir is excreted 94% via the faeces, and only 0.4% through urine. The Biological half-life is about 15 hours. Some of the commonly used Genric Epclusa(Velpatasvir 100mg with Sofosbuvir 400mg) combination tablets available in India
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